| Corneal markers of diabetic neuropathy. | |
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MedLine Citation:
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PMID: 21338566 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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ABSTRACT Diabetic neuropathy is a significant clinical problem that currently has no effective therapy, and in advanced cases, leads to foot ulceration and lower limb amputation. The accurate detection, characterization and quantification of this condition are important in order to define at-risk patients, anticipate deterioration, monitor progression, and assess new therapies. This review evaluates novel corneal methods of assessing diabetic neuropathy. Two new noninvasive corneal markers have emerged, and in cross-sectional studies have demonstrated their ability to stratify the severity of this disease. Corneal confocal microscopy allows quantification of corneal nerve parameters and noncontact corneal esthesiometry, the functional correlate of corneal structure, assesses the sensitivity of the cornea. Both these techniques are quick to perform, produce little or no discomfort for the patient, and are suitable for clinical settings. Each has advantages and disadvantages over traditional techniques for assessing diabetic neuropathy. Application of these new corneal markers for longitudinal evaluation of diabetic neuropathy has the potential to reduce dependence on more invasive, costly, and time-consuming assessments, such as skin biopsy. |
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Authors:
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Nicola Pritchard; Katie Edwards; Ayda M Shahidi; Geoff P Sampson; Anthony W Russell; Rayaz A Malik; Nathan Efron |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The ocular surface Volume: 9 ISSN: 1542-0124 ISO Abbreviation: Ocul Surf Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-02-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101156063 Medline TA: Ocul Surf Country: United States |
Other Details:
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Languages: eng Pagination: 17-28 Citation Subset: IM |
Affiliation:
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From the Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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