Document Detail


Corneal hydration control in Fuchs' dystrophy.
MedLine Citation:
PMID:  2785979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corneal hydration control was tested in 22 patients with Fuchs' dystrophy, and eight subjects of similar age without the disease, by measuring the corneal thickness recovery from swelling induced by hypoxia or following overnight sleep. Measurement precision was enhanced by using a modified optical pachometer and conducting two test procedures which were analyzed by a coupled exponential model. We have identified three parameters of the recovery from corneal swelling which may be used to describe hydration control: percent recovery per hour (PRPH) (mean 25.4% for Fuchs' and 34.2% for normals), time for 95% of corneal thickness recovery (mean 10.2 hr for Fuchs' and 7.1 hr for normals), and the open-eye steady-state thickness (mean 562 microns for Fuchs' and 537 microns for normals.) A PRPH of 17.1%/hr was identified as the minimum below which the cornea could not regain its open-eye steady state during the entire day and approaches decompensation. Our test procedure quantifies the corneal hydration control mechanism and may provide a test of endothelial function which can be used to monitor the progression of Fuchs' disease and guide decisions related to corneal surgery.
Authors:
R B Mandell; K A Polse; R J Brand; D Vastine; D Demartini; R Flom
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  30     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-26     Completed Date:  1989-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  845-52     Citation Subset:  IM    
Affiliation:
School of Optometry, University of California, Berkeley 94720.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anoxia / metabolism,  pathology
Body Water / metabolism*
Cornea / metabolism*,  pathology
Corneal Dystrophies, Hereditary / metabolism*
Female
Fuchs' Endothelial Dystrophy / metabolism*,  pathology
Homeostasis
Humans
Male
Middle Aged
Models, Biological
Occlusive Dressings
Sleep / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
EY-04930/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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