Document Detail

Corneal crystallins and the development of cellular transparency.
MedLine Citation:
PMID:  17997336     Owner:  NLM     Status:  MEDLINE    
Past studies have established that the cornea like the lens abundantly expresses a few water-soluble enzyme/proteins in a taxon specific fashion. Based on these similarities it has been proposed that the lens and the cornea form a structural unit, the 'refracton', that has co-evolved through gene sharing to maximize light transmission and refraction to the retina. Thus far, the analogy between corneal crystallins and lens crystallins has been limited to similarities in the abundant expression, with few reports concerning their structural function. This review covers recent studies that establish a clear relationship between expression of corneal crystallins and light scattering from corneal stromal cells, i.e. keratocytes, that support a structural role for corneal crystallins in the development of transparency similar to that of lens crystallins that would be consistent with the 'refracton' hypothesis.
James V Jester
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-10-02
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  19     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-06-19     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  82-93     Citation Subset:  IM    
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MeSH Terms
Cornea / metabolism*
Corneal Opacity / etiology,  genetics
Corneal Stroma / physiology
Crystallins / genetics,  metabolism,  physiology*
Epithelium, Corneal / embryology,  physiology
Gene Expression Regulation, Developmental
Lens, Crystalline / embryology*,  physiology*
Scattering, Radiation
Grant Support
EY 13215/EY/NEI NIH HHS; EY 16663/EY/NEI NIH HHS; EY 17963/EY/NEI NIH HHS; R01 EY013215/EY/NEI NIH HHS; R01 EY013215-04/EY/NEI NIH HHS
Reg. No./Substance:

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