Document Detail


Corneal biomechanics in iatrogenic ectasia and keratoconus: A review of the literature.
MedLine Citation:
PMID:  23772119     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The Ocular Response Analyzer (ORA) (Reichert Ophthalmic Instruments, Buffalo, NY) allows direct measurement of corneal biomechanical properties. Since its introduction, many studies have sought to elucidate the clinical applications of corneal hysteresis (CH) and corneal resistance factor (CRF). More recently, detailed corneal deformation signal waveform analysis (WA) has potentially expanded the diagnostic capabilities of the ORA. In this review, the role of CH, CRF, and WA are examined in keratoconus (KC) and iatrogenic ectasia (IE). The PubMed database was searched electronically for peer-reviewed literature in July 2012 and August 2012 without date restrictions. The search strategy included medical subject heading (MeSH) and natural language terms to retrieve references on corneal biomechanics, CH, CRF, corneal deformation signal WA, IE, and KC. The evidence suggests that while CH and CRF are poor screening tools when used alone, increased sensitivity and specificity of KC and IE screening result when these parameters are combined with tomography and topography. Recent advances in WA are promising, but little is currently understood about its biomechanical and clinical relevance. Future studies should seek to refine the screening protocols for KC and IE as well as define the clinical applicability of WA parameters.
Authors:
Majid Moshirfar; Jason N Edmonds; Nicholas L Behunin; Steven M Christiansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oman journal of ophthalmology     Volume:  6     ISSN:  0974-620X     ISO Abbreviation:  Oman J Ophthalmol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-06-17     Completed Date:  2013-06-18     Revised Date:  2013-06-21    
Medline Journal Info:
Nlm Unique ID:  101519430     Medline TA:  Oman J Ophthalmol     Country:  India    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  -    
Affiliation:
Department of Ophthalmology, John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
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