| Corneal biomechanical characteristics in patients with diabetes mellitus. | |
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MedLine Citation:
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PMID: 21029887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare the corneal biomechanical properties in eyes of patients with diabetes mellitus and in those of subjects without diabetes mellitus. SETTING: Hospital eye clinic. DESIGN: Comparative case series. METHODS: Corneal hysteresis (CH) and corneal response factor (CRF) were measured in diabetic patients and nondiabetic subjects using the Ocular Response Analyzer. Central corneal thickness (CCT) and intraocular pressure (IOP) were also measured. Differences in corneal biomechanical properties were determined using a 1-way analysis of variance. Interassociations between ocular and diabetic parameters were also evaluated. RESULTS: Sixty-one eyes of 61 diabetic patients and 123 eyes of 123 nondiabetic subjects were evaluated. The CRF was significantly greater in the eyes of diabetic patients (mean difference, 1.09 mm Hg; 95% confidence interval [CI], 0.49-1.69; P = .001). There were no significant differences in CCT or CH between groups (CH: mean difference, 0.38 mm Hg; 95% CI, -0.21 to 0.97 mm Hg; P = .21; CCT: mean difference, 0.13 μm; 95% CI, -10.6 to 10.8 μm; P =.98). Corneal hysteresis and CRF were weakly correlated with blood glucose concentration (slopes: CH: 0.28; 95% CI, 0.03-0.50; P = .03; CRF: 0.27; 95% CI 0.02-0.49; P = .04). In a multiple regression analysis, the effects of blood glucose concentration were reduced and age and CCT became significant predictors of CH and CRF. CONCLUSIONS: The eyes in diabetic patients displayed altered corneal biomechanics that may be related to blood glucose concentration. Further studies are required to establish the effects of long-term poor glucose control on corneal biomechanical properties and how this might affect the diabetic patient's response to refractive surgery procedures. |
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Authors:
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Aachal Kotecha; Francesco Oddone; Christos Sinapis; Ahmed Elsheikh; Dimitros Sinapis; Angelos Sinapis; David F Garway-Heath |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cataract and refractive surgery Volume: 36 ISSN: 1873-4502 ISO Abbreviation: J Cataract Refract Surg Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8604171 Medline TA: J Cataract Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1822-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, UK. aachalkotecha@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biomechanics / physiology* Blood Glucose / metabolism Cornea / physiology* Diabetes Mellitus / blood, physiopathology* Female Hemoglobin A, Glycosylated / metabolism Humans Intraocular Pressure / physiology Male Middle Aged Time Factors Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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