| Corneal sensitivity as an ophthalmic marker of diabetic neuropathy. | |
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MedLine Citation:
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PMID: 21037498 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: The objective of this study was to explore the discriminative capacity of non-contact corneal esthesiometry (NCCE) when compared with the neuropathy disability score (NDS) score-a validated, standard method of diagnosing clinically significant diabetic neuropathy. METHODS: Eighty-one participants with type 2 diabetes, no history of ocular disease, trauma, or surgery and no history of systemic disease that may affect the cornea were enrolled. Participants were ineligible if there was history of neuropathy due to non-diabetic cause or current diabetic foot ulcer or infection. Corneal sensitivity threshold was measured on the eye of dominant hand side at a distance of 10 mm from the center of the cornea using a stimulus duration of 0.9 s. The NDS was measured producing a score ranging from 0 to 10. To determine the optimal cutoff point of corneal sensitivity that identified the presence of neuropathy (diagnosed by NDS), the Youden index and "closest-to-(0,1)" criteria were used. RESULTS: The receiver-operator characteristic curve for NCCE for the presence of neuropathy (NDS ≥3) had an area under the curve of 0.73 (p = 0.001) and, for the presence of moderate neuropathy (NDS ≥6), area of 0.71 (p = 0.003). By using the Youden index, for an NDS ≥3, the sensitivity of NCCE was 70% and specificity was 75%, and a corneal sensitivity threshold of 0.66 mbar or higher indicated the presence of neuropathy. When NDS ≥6 (indicating risk of foot ulceration) was applied, the sensitivity was 52% with a specificity of 85%. CONCLUSIONS: NCCE is a sensitive test for the diagnosis of minimal and more advanced diabetic neuropathy and may serve as a useful surrogate marker for diabetic and perhaps other neuropathies. |
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Authors:
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Nicola Pritchard; Katie Edwards; Dimitrios Vagenas; Ayda M Shahidi; Geoff P Sampson; Anthony W Russell; Rayaz A Malik; Nathan Efron |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Optometry and vision science : official publication of the American Academy of Optometry Volume: 87 ISSN: 1538-9235 ISO Abbreviation: Optom Vis Sci Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904931 Medline TA: Optom Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1003-8 Citation Subset: IM |
Affiliation:
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Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. n.pritchard@qut.edu.au |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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