Document Detail

Corneal endothelial morphologic features in toxic anterior segment syndrome.
MedLine Citation:
PMID:  20098309     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the clinical and laboratory findings of toxic anterior segment syndrome (TASS) following cataract surgery with intraocular lens (IOL) implantation, with emphasis on the morphologic features of the corneal endothelium. METHODS: A single-center retrospective observational case-control design was used. The sample consisted of 15 patients (mean age 60.3 +/- 11.2 years) with a diagnosis of TASS following unilateral cataract surgery with IOL implantation. In all cases, cataract surgery with IOL implantation had already been performed in the fellow pseudophakic eye without complications. Data on the corneal endothelial morphologic features in both eyes were collected from the files as follows: endothelial cell density, coefficient of variation of cell size, and percentage of hexagonal cells. Values in the eyes with TASS (study group) were compared with the fellow eyes (control group). Between-group differences were analyzed with Student's t test at a significance level of 5%. RESULTS: The eyes with TASS were characterized by a significantly lower endothelial cell density than the control eyes (2302 +/- 220 cells/mm vs. 2853 +/- 145 cells/mm), higher mean cell area (coefficient of variation; 38 +/- 1.4 vs. 24 +/- 2.5), and lower mean percentage of hexagonal cells (22 +/- 1.5% vs. 48 +/- 3.2%; P < 0.01 for all). Common presenting symptoms and signs were blurred vision (60%), anterior segment inflammation (100%), and cell deposition (20%). CONCLUSIONS: TASS following cataract surgery with intraocular lens implantation is associated with a low corneal endothelial cell density.
Rahamim Avisar; Dov Weinberger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cornea     Volume:  29     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-24     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
External Eye Disease Clinic, Department of Ophthalmology, Rabin Medical Center, Golda Campus, Petah Tiqwa, Israel.
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MeSH Terms
Anterior Eye Segment / drug effects,  pathology*
Atropine / administration & dosage
Case-Control Studies
Cell Count
Corneal Endothelial Cell Loss / diagnosis,  drug therapy,  etiology*
Endothelium, Corneal / pathology*
Glucocorticoids / administration & dosage
Lens Implantation, Intraocular
Middle Aged
Phacoemulsification / adverse effects*
Retrospective Studies
Uveitis, Anterior / diagnosis,  drug therapy,  etiology*
Reg. No./Substance:
0/Glucocorticoids; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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