Document Detail


Corneal Cross-Linking as Supplementary Treatment Option in Melting Keratitis: A Case Series.
MedLine Citation:
PMID:  22496015     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Corneal melting represents a serious condition that can result in corneal perforation and loss of vision. Treatment options include topical and systemic immunosuppression, cyanoacrylate gluing, and emergency keratoplasty, depending on the underlying disease and the stage of corneal melt. Recently, corneal cross-linking (CXL) has emerged as an additional treatment option. The present study evaluates whether CXL induces a clinical improvement in melting keratitis not responding to conventional treatment. History and Signs: Six patients undergoing CXL for corneal melting of variable origin (including bacterial, fungal and Acanthamoeba keratitis) were reviewed retrospectively. Therapy and Outcome: Treatment parameters included riboflavin application following UV irradiation with a wavelength of 370 nm and an irradiance of 3 mW/cm2 for 30 minutes. Four patients with corneal melting due to contact lens-related infectious keratitis showed healing without any need for further interventions up to date. In two patients, CXL stabilized the melting cornea and facilitated additional surgical procedures.Conclusions: By stabilizing corneal collagen fibres, CXL seems to represent an effective option to re-establish corneal integrity in the event of pending perforations. In established perforations, CXL facilitates further emergency procedures by stiffening the tissue.
Authors:
L Müller; M A Thiel; A I Kipfer-Kauer; C Kaufmann
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-11
Journal Detail:
Title:  Klinische Monatsblatter fur Augenheilkunde     Volume:  229     ISSN:  1439-3999     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0014133     Medline TA:  Klin Monbl Augenheilkd     Country:  -    
Other Details:
Languages:  ENG     Pagination:  411-415     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Vernacular Title:
Corneales Crosslinking als zusätzliche Therapieoption bei einschmelzender Hornhaut: eine Fall-Serie.
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