Document Detail


Corn starches as film formers in aqueous-based film coating.
MedLine Citation:
PMID:  11485177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the film formation ability and mechanical stress-strain properties of aqueous native corn starches, using free films and film coatings applied to tablets. Free films were prepared from high-amylose corn (Hylon VII), corn and waxy corn starches, using sorbitol and glycerol as plasticizers. The tablets and pellets were film-coated using an air-suspension coater, and characterized with respect to the film coating surface topography, cross-sectional structure and thickness (SEM), and dissolution in vitro. The amylose content of the starch film formers affected both the tensile strength and the elongation. The elongations were under 5% for even the plasticized starches, and in most cases, no plasticization effect was seen by either of the plasticizers. Dissolution of native corn starch film-coated tablets (weight gain 1%) did not differ from uncoated ones. A notable delay in dissolution of the drug was found by increasing Hylon VII film coating thickness, suggesting controlled-release characteristics.
Authors:
P Palviainen; J Heinämäki; P Myllärinen; R Lahtinen; J Yliruusi; P Forssell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  6     ISSN:  1083-7450     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-03     Completed Date:  2002-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  353-61     Citation Subset:  IM    
Affiliation:
Department of Pharmacy, University of Helsinki, Finland. paivi.palviainen@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Amylose / chemistry,  ultrastructure
Chemistry, Pharmaceutical
Microscopy, Electron, Scanning
Solubility
Starch / chemistry*,  ultrastructure
Stress, Mechanical
Surface Properties
Tablets
Water*
Chemical
Reg. No./Substance:
0/Tablets; 7732-18-5/Water; 9005-25-8/Starch; 9005-82-7/Amylose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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