| Corin: a key protein of an adaptive renal mechanism to respond to salt variation? | |
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MedLine Citation:
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PMID: 22699378 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The protease corin generates atrial natriuretic peptide and affects blood pressure and salt-water homeostasis. Under dietary salt challenge, corin knockout mice show blood pressure exacerbation and significant weight gain due to water and salt retention. This phenotype involves the epithelial sodium channel but is independent of the renin-angiotensin-aldosterone system. This suggests that corin has an important role in a new adaptive mechanism of the response to variations of salt in the diet. |
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Authors:
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Richard Bouley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Kidney international Volume: 82 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 7-8 Citation Subset: IM |
Affiliation:
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Program in Membrane Biology, Massachusetts General Hospital, Boston, Massachusetts, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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