Document Detail

Corin: a key protein of an adaptive renal mechanism to respond to salt variation?
MedLine Citation:
PMID:  22699378     Owner:  NLM     Status:  MEDLINE    
The protease corin generates atrial natriuretic peptide and affects blood pressure and salt-water homeostasis. Under dietary salt challenge, corin knockout mice show blood pressure exacerbation and significant weight gain due to water and salt retention. This phenotype involves the epithelial sodium channel but is independent of the renin-angiotensin-aldosterone system. This suggests that corin has an important role in a new adaptive mechanism of the response to variations of salt in the diet.
Richard Bouley
Related Documents :
18158348 - Pulse pressure is inversely related to aortic root diameter implications for the pathog...
12574788 - Bone mass and bone modelling markers in hypertensive postmenopausal women.
10212338 - Seasonal variations in office and home blood pressures in hypertensive patients treated...
11909568 - Changes in hemodynamics and left ventricular structure after menopause.
23713578 - Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage.
7381778 - Haemodynamic responses to stimulation of the cardiac autonomic nerves in the anaestheti...
Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  82     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-29     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure*
Hypertension / enzymology*
Kidney / enzymology*
Serine Endopeptidases / deficiency*
Grant Support
Reg. No./Substance:
EC 3.4.21.-/Corin protein, mouse; EC 3.4.21.-/Serine Endopeptidases
Comment On:
Kidney Int. 2012 Jul;82(1):26-33   [PMID:  22418978 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bioavailable vitamin D in chronic kidney disease.
Next Document:  Tissue dynamics with permeation.