Document Detail


Corin: a key protein of an adaptive renal mechanism to respond to salt variation?
MedLine Citation:
PMID:  22699378     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The protease corin generates atrial natriuretic peptide and affects blood pressure and salt-water homeostasis. Under dietary salt challenge, corin knockout mice show blood pressure exacerbation and significant weight gain due to water and salt retention. This phenotype involves the epithelial sodium channel but is independent of the renin-angiotensin-aldosterone system. This suggests that corin has an important role in a new adaptive mechanism of the response to variations of salt in the diet.
Authors:
Richard Bouley
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  82     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-15     Completed Date:  2012-10-29     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Hypertension / enzymology*
Kidney / enzymology*
Male
Natriuresis*
Serine Endopeptidases / deficiency*
Grant Support
ID/Acronym/Agency:
P01 DK038452-13/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
EC 3.4.21.-/Corin protein, mouse; EC 3.4.21.-/Serine Endopeptidases
Comments/Corrections
Comment On:
Kidney Int. 2012 Jul;82(1):26-33   [PMID:  22418978 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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