| Corin: an ANP protease that may regulate sodium reabsorption in nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 20842148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The serine/threonine protease corin, which proteolytically activates atrial natriuretic peptide (ANP), is reduced in the kidneys of animals with nephrotic syndrome and glomerular nephritis. Polzin et al. provide evidence for a linkage between the decreased corin and β-epithelial sodium channel, phosphodiesterase 5, and cGMP-dependent protein kinase II in the nephrotic kidney. They propose that decreases in cGMP resulting from the reduced corin may be responsible for the Na(+) retention and volume expansion that are hallmarks of these kidney diseases. |
| | |
Authors:
|
Janet D Klein |
Related Documents
:
|
10711418 - Minimal change glomerulonephritis associated with hydatid disease. 16183408 - Glomerular tip lesion associated with nonsteroidal anti-inflammatory drug-induced nephr... 8247198 - Simultaneous occurrence of iga nephropathy and sarcoidosis in the context of pre-existe... 2136288 - Nephrotic syndrome in two members of a family with mercury poisoning. 8869188 - Focal abnormalities detected by 18fdg pet in epileptic encephalopathies. 10220988 - The reappearance of polio. postpolio syndrome. |
Publication Detail:
|
Type: Comment; Journal Article |
Journal Detail:
|
Title: Kidney international Volume: 78 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-15 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 635-7 Citation Subset: IM |
Affiliation:
|
Department of Renal Medicine, Emory University, Atlanta, Georgia 30322, USA. jklei01@emory.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorption Animals Atrial Natriuretic Factor / metabolism Cyclic GMP / physiology Cyclic Nucleotide Phosphodiesterases, Type 5 / physiology Humans Nephrotic Syndrome / metabolism* Serine Endopeptidases / physiology* Sodium / metabolism* |
| Chemical | |
Reg. No./Substance:
|
7440-23-5/Sodium; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC 3.1.4.35/Cyclic Nucleotide Phosphodiesterases, Type 5; EC 3.1.4.35/Pde5a protein, mouse; EC 3.4.21.-/CORIN protein, human; EC 3.4.21.-/Serine Endopeptidases |
| Comments/Corrections | |
Comment On:
|
Kidney Int. 2010 Oct;78(7):650-9
[PMID:
20613715
]
|
Comment In:
|
Kidney Int. 2011 Jan;79(1):138-9
[PMID:
21157466
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Obesity-related renal damage: changing diet to avoid progression.
Next Document: Kidney transplantation from older donors: proceed with caution.