| Corelease of GABA/glycine in lamina-X of the spinal cord of neonatal rats. | |
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MedLine Citation:
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PMID: 17558289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spinal-cord slices from neonatal rats were used to record lamina-X neurons using the patch-clamp technique under whole cell recording configuration. Lamina-X surrounds the central canal of the spinal cord and contains sympathetic preganglionic neurons of the central autonomic nucleus. Miniature inhibitory postsynaptic currents were recorded in the presence of tetrodotoxin and kynurenic acid to block action potential-dependent transmitter release and glutamatergic transmissions, respectively. We recorded mixed gamma-amino-n-butyric acid/glycine miniature synaptic currents suggesting that gamma-amino-n-butyric acid and glycine can be coreleased from the same single synaptic vesicles, and that this corelease can be detected by the postsynaptic cell. In addition, acetylcholine can induce the release of gamma-amino-n-butyric acid/glycine by acting presynaptically at nicotinic receptors located on the gamma-amino-n-butyric acid ergic/glycinergic terminals. |
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Authors:
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Riad Seddik; Rémy Schlichter; Jérôme Trouslard |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroreport Volume: 18 ISSN: 0959-4965 ISO Abbreviation: Neuroreport Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1025-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Basel, Pharmazentrum, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Anesthetics, Local / pharmacology Animals Animals, Newborn Bicuculline / pharmacology Drug Interactions Excitatory Amino Acid Antagonists / pharmacology GABA Antagonists / pharmacology Glycine / metabolism*, pharmacology Glycine Agents / pharmacology Inhibitory Postsynaptic Potentials / drug effects, physiology Kynurenic Acid / pharmacology Neural Inhibition / physiology Neurons / drug effects, physiology Patch-Clamp Techniques / methods Rats Strychnine / pharmacology Substantia Gelatinosa / cytology, metabolism* Tetrodotoxin / pharmacology gamma-Aminobutyric Acid / metabolism*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Excitatory Amino Acid Antagonists; 0/GABA Antagonists; 0/Glycine Agents; 4368-28-9/Tetrodotoxin; 485-49-4/Bicuculline; 492-27-3/Kynurenic Acid; 51-84-3/Acetylcholine; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 57-24-9/Strychnine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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