| Coregistration of diffuse optical spectroscopy and magnetic resonance imaging in a rat tumor model. | |
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MedLine Citation:
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PMID: 12790444 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report coregistration of near-infrared diffuse optical spectroscopy (DOS) and magnetic resonance imaging (MRI) for the study of animal model tumors. A combined broadband steady-state and frequency-domain apparatus was used to determine tissue oxyhemoglobin, deoxyhemoglobin, and water concentration locally in tumors. Simultaneous MRI coregistration provided structural (T2-weighted) and contrast-enhanced images of the tumor that were correlated with the optical measurements. By use of Monte Carlo simulations, the optically sampled volume was superimposed on the MR images, showing precisely which tissue structure was probed optically. DOS and MRI coregistration measurements were performed on seven rats over 20 days and were separated into three tumor tissue classifications: viable, edematous, and necrotic. A ratio of water concentration to total hemoglobin concentration, as measured optically, was performed for each tissue type and showed values for edematous tissue to be greater than viable tissue (1.2 +/- 0.49 M/microM versus 0.48 +/- 0.15 M/microM). Tissue hemoglobin oxygen saturation (StO2) also showed a large variation between tissue types: viable tissue had an optically measured StO2 value of 61 +/- 5%, whereas StO2 determined for necrotic tissue was 43 +/- 6%. |
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Authors:
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Sean Merritt; Frederic Bevilacqua; Anthony J Durkin; David J Cuccia; Ryan Lanning; Bruce J Tromberg; Gultekin Gulsen; Hon Yu; Jun Wang; Orhan Nalcioglu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Applied optics Volume: 42 ISSN: 0003-6935 ISO Abbreviation: Appl Opt Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-06 Completed Date: 2003-07-02 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0247660 Medline TA: Appl Opt Country: United States |
Other Details:
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Languages: eng Pagination: 2951-9 Citation Subset: IM |
Affiliation:
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Laser Microbeam and Medical Program, Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis* Animals Female Magnetic Resonance Imaging* Neoplasm Transplantation Optics and Photonics* Rats Rats, Inbred F344 Skin Neoplasms / diagnosis* |
| Grant Support | |
ID/Acronym/Agency:
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P20-CA86182/CA/NCI NIH HHS; RR01192/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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