| Core temperature influences on the relationship between exercise-induced leukocytosis and cortisol or TNF-alpha. | |
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MedLine Citation:
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PMID: 20464812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The extent to which exercise in the heat modifies leukocytosis and the relationship between the leukocytosis and tumor necrosis factor-alpha (TNF-alpha) or cortisol is not well understood. Thus, this study attempted to determine the combined effect of exercise and differing elevations in core temperature on exercise-induced leukocytosis and to examine associations between any leukocytosis and cortisol orTNF-alpha. METHODS: Eight male subjects completed two 40-min trials while immersed in 25 and 38.5 degrees C water. Leukocytes, TNF-alpha, and cortisol were determined at baseline, immediately post-, and 2 h post-exercise. RESULTS: Both trials resulted in significant 13-33% increases in total leukocytes, mostly driven by a 24-30% increase in neutrophils. A significant relationship was found between the change in core temperature (T(re)) during exercise and the increase in total leukocytes (r = 0.561). Similarly, the change in T(re) was related to the change in cortisol (r = 0.557) and TNF-alpha (r = 0.483). Yet the exercise-induced change in cortisol was not significantly correlated to any changes in leukocytes. There was a trend for the relationships between the exercise-induced change in TNF-alpha and the changes in total leukocytes (r = 0.491) and neutrophils (r = 0.479). DISCUSSION: These results suggest that although neither cortisol nor TNF-alpha are strong predictors of the leukocyte response during exercise or recovery, each factor may be one of many potential modifiers of the total leukocyte response. |
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Authors:
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Erica S Cooper; Mark P Berry; Robert G McMurray; Peter A Hosick; Anthony C Hackney |
Publication Detail:
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Type: Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Aviation, space, and environmental medicine Volume: 81 ISSN: 0095-6562 ISO Abbreviation: Aviat Space Environ Med Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501714 Medline TA: Aviat Space Environ Med Country: United States |
Other Details:
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Languages: eng Pagination: 460-6 Citation Subset: IM; S |
Affiliation:
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Applied Physiology Laboratory, Department of Exercise and Sport Science, CB# 8700, Fetzer Gym, University of North Carolina, Chapel Hill, NC 27599-9700, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Temperature / physiology* Exercise / physiology* Hot Temperature* Humans Hydrocortisone / blood* Immersion Leukocytosis* Male Tumor Necrosis Factor-alpha / blood* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Necrosis Factor-alpha; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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