Document Detail

Core temperature is a greater influence than endogenous 17β-estradiol on the exercise-induced accumulation of myocardial heat shock protein mRNA.
MedLine Citation:
PMID:  22039956     Owner:  NLM     Status:  Publisher    
Female rats typically do not show significant increases in myocardial Hsp70 after exercise unless trained (exercise over days or weeks). 17β-Estradiol (E2) has been linked to this inhibition, but it varies considerably over the rodent estrus cycle. Consequently, we examined whether the inhibitory effects of endogenously produced E2 (measured immediately pre-exercise) were acute in exercised female Sprague-Dawley rats (60 min treadmill running at 30 m·min(-1)). Myocardial hsp70-1 and hsp70-2 mRNA were measured 30 min post-exercise, and their expression was inversely correlated with pre-exercise plasma Ε2 ( hsp70-1 mRNA, r(2) = 0.308, p = 0.011; hsp70-2 mRNA, r(2) = 0.238, p = 0.029). However, hsp70-1 and hsp70-2 mRNA exhibited much stronger correlations with core temperature achieved during exercise (r(2) = 0.812, p = 0.000; and r(2) = 0.738, p = 0.000, respectively). Consequently, although endogenous Ε2 in gonadally intact female rats may attenuate myocardial hsp70 mRNA accumulation, suggesting a reason why training maximizes this response in females, core temperature during exercise is still a greater stimulus to this response.
Kevin J Milne; David B Thorp; Matt Krause; Earl G Noble
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-1
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  -     ISSN:  1205-7541     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a School of Kinesiology, Faculty of Health Sciences, The University of Western Ontario London, ON N6A 3K7, Canada.
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