| Cordlan polysaccharide isolated from mushroom Cordyceps militaris induces dendritic cell maturation through toll-like receptor 4 signalings. | |
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MedLine Citation:
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PMID: 20434503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Defect of dendritic cell (DC) maturation in tumor microenvironments is an important immunological problem limiting the success of cancer immunotherapy. Here, we investigated the effects of polysaccharide (cordlan) isolated from Cordyceps militaris on DC maturation. Phenotypic maturation of DCs by cordlan was demonstrated by the elevated expressions of CD40, CD80, CD86, MHC-I, and MHC-II molecules, and functional maturation by increased expression of IL-12, IL-1beta, TNF-alpha, and IFN-alphabeta, enhanced allogenic T cell stimulation, and decreased endocytosis. Of note was that cordlan induced maturation of tlr4+/+ DCs from C3H/HeN mice, but not tlr4(-/-) DCs from C3H/HeJ mice, suggesting the promising membrane receptor of cordlan. In addition, cordlan increased phosphorylation of ERK, p38, and JNK, and nuclear translocation of NF-kappaB p50/p65, which were main signaling molecules down-stream from TLR4. These results indicate that cordlan induces DC maturation through TLR4 signaling pathways. |
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Authors:
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Hyung Sook Kim; Jee Youn Kim; Jong Soon Kang; Hwan Mook Kim; Yong Ook Kim; In Pyo Hong; Mi Kyeong Lee; Jin Tae Hong; Youngsoo Kim; Sang-Bae Han |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-29 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1926-33 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Cell Separation Cordyceps / chemistry* Cytokines / metabolism Dendritic Cells / drug effects* Endocytosis / drug effects Female Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mitogen-Activated Protein Kinases / metabolism NF-kappa B p50 Subunit / metabolism Polysaccharides / chemistry, pharmacology* Protein Transport / drug effects Signal Transduction / drug effects T-Lymphocytes / drug effects Toll-Like Receptor 4 / drug effects* Transcription Factor RelA / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/NF-kappa B p50 Subunit; 0/Polysaccharides; 0/Toll-Like Receptor 4; 0/Transcription Factor RelA; EC 2.7.11.24/Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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