Document Detail

Cord serum glycodelin concentrations in normal pregnancies and pregnancies complicated by diabetes.
MedLine Citation:
PMID:  12955531     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Glycodelin is a glycoprotein released by secretory/decidualized endometrial glands. Its synthesis increases during pregnancy. Hormonal factors whose levels have been shown to change in diabetes (vascular endothelial growth factor, relaxin) may mediate the actions or regulate the synthesis of glycodelin. Cord serum glycodelin levels have not been studied in pregnancies complicated by diabetes. METHODS: Cord serum glycodelin concentrations were measured at birth by an immunofluorometric assay in 62 normal pregnancies, in 67 pregnancies complicated by type 1 diabetes, and in 28 pregnancies complicated by insulin-treated gestational diabetes. RESULTS: The mean glycodelin concentration in cord serum was 2.7 ng/ml (standard error of the mean 0.6) in normal pregnancies. The concentration was not altered in pregnancies complicated by diabetes. Cord serum glycodelin concentrations were also unaltered in diabetic pregnancies with hypertensive disorders (chronic hypertension, pregnancy-induced hypertension or pre-eclampsia) or fetal macrosomia. There was a negative borderline correlation between cord serum glycodelin concentrations and the birth weight in pregnancies complicated by diabetes (r=-0.21, p=0.049). CONCLUSIONS: Decidual function, as assessed by cord serum glycodelin levels, is not markedly altered in diabetic pregnancies. The negative correlation between cord serum glycodelin and the birth weight of the newborns in diabetic pregnancies may be due to the decline in glycodelin levels with advancing pregnancy in the third trimester.
Mikko Loukovaara; Pekka Leinonen; Kari Teramo; Riitta Koistinen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-08-30
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  270     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-04     Completed Date:  2005-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, 00290 Helsinki, Finland.
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MeSH Terms
Case-Control Studies
Diabetes, Gestational / blood*
Fetal Blood / metabolism*
Glycoproteins / blood*
Pregnancy / blood
Pregnancy Proteins / blood*
Pregnancy in Diabetics / blood*
Reg. No./Substance:
0/Glycoproteins; 0/PAEP protein, human; 0/Pregnancy Proteins

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