Document Detail

Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity.
MedLine Citation:
PMID:  15212649     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Adiponectin is negatively associated with leptin, insulin and obesity in children and adults. Whereas increases in fetal insulin and leptin are associated with increased weight and adiposity at birth, the role of adiponectin in fetal growth has not yet been determined. The aims of this study were to examine the relationships between adiponectin and insulin, leptin, weight and adiposity at birth in healthy term infants. DESIGN AND METHODS: Anthropometric parameters including weight, length, circumferences and skinfold thickness were measured, and plasma lipid profiles, insulin, leptin and adiponectin concentrations in cord blood samples from 226 singleton infants born at term after uncomplicated pregnancies were assayed. RESULTS: Cord plasma adiponectin, leptin and insulin levels correlated significantly and positively with birthweight (P = 0.001, P < 0.001, P < 0.001, respectively) and the sum of skinfold thicknesses (P < 0.001, P < 0.001, P < 0.001, respectively). Mean cord plasma adiponectin and leptin levels, but not insulin level, were significantly higher in large-for-gestational-age (LGA) infants compared with appropriate-for-gestational-age (AGA) infants. Cord plasma leptin concentration, but not adiponectin concentration, was significantly higher in female infants than in male infants (P = 0.003 and P = 0.94, respectively). Cord plasma adiponectin concentration correlated positively with leptin level (P = 0.007) but not with insulin level (P = 0.78). CONCLUSIONS: High adiponectin levels are present in the cord blood. Cord plasma adiponectin and leptin levels are positively correlated with birthweight and adiposity. This suggests that adiponectin may be involved in regulating fetal growth.
Po-Jung Tsai; Chun-Hsien Yu; Shih-Penn Hsu; Yu-Hsiang Lee; Chuen-Hua Chiou; Yu-Wen Hsu; Su-Chen Ho; Chun-Hong Chu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  61     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-23     Completed Date:  2004-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  88-93     Citation Subset:  IM    
Department of Food Science, and Institute of Biotechnology, Yuanpei University of Science and Technology, Hsin-Chu, Taiwan.
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MeSH Terms
Adipose Tissue / anatomy & histology*
Biological Markers / blood
Birth Weight*
Embryonic and Fetal Development / physiology
Fetal Blood / chemistry*
Gender Identity
Infant, Newborn / blood*
Insulin / blood
Intercellular Signaling Peptides and Proteins*
Leptin / blood*
Prospective Studies
Proteins / analysis*
Skinfold Thickness
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin; 0/Proteins; 11061-68-0/Insulin

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