Document Detail

Cord plasma alpha-fetoprotein values and neonatal jaundice.
MedLine Citation:
PMID:  6209608     Owner:  NLM     Status:  MEDLINE    
Umbilical cord plasma alpha-fetoprotein (AFP) values were determined in 127 infants with hyperbilirubinemia (56 glucose-6-phosphate dehydrogenase (G-6-PD) deficient and 71 G-6-PD normal) and 136 control subjects (73 G-6-PD deficient and 63 G-6-PD normal). The mean alpha-fetoprotein value of 173 +/- 35.2 (SD) mg/L for the group of infants with hyperbilirubinemia was significantly greater than that (122 +/- 21.7 mg/L) for the control infants (P less than .001). G-6-PD status and sex did not significantly affect the alpha-fetoprotein values. Using an alpha-fetoprotein level of 130 mg/L as a "cut-off" value, the incidence of false-positive results was 25.5% and the incidence of false-negative results was 11.8%. This test can be used as a screening procedure to detect infants at high risk for hyperbilirubinemia.
K L Tan; A Loganath; A C Roy; H H Goh; S M Karim; S S Ratnam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  74     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-09     Completed Date:  1985-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1065-8     Citation Subset:  AIM; IM    
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MeSH Terms
China / ethnology
False Negative Reactions
False Positive Reactions
Fetal Blood / analysis*
Glucosephosphate Dehydrogenase Deficiency / blood,  complications
Infant, Newborn
Jaundice, Neonatal / blood*,  complications,  diagnosis
alpha-Fetoproteins / analysis*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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