| Cord leptin level and fetal macrosomia. | |
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MedLine Citation:
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PMID: 11042305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the relationships among serum leptin, insulin-like growth factor-I, and insulin levels in large for gestational age (LGA) infants. METHODS: Serum samples were collected from maternal veins and umbilical arteries of 52 consecutive, term, LGA neonates of nondiabetic mothers. Maternal and neonatal serum samples were analyzed for levels of leptin, insulin-like growth factor-I, and insulin by specific radioimmunoassays. Multiple regression analysis was used to determine independent risk factors for fetal macrosomia. RESULTS: The independent risk factor significantly associated with fetal macrosomia was umbilical cord leptin concentration (P <.01, beta = 0.59). There was a statistically significant correlation between umbilical cord leptin and insulin-like growth factor-I levels and birth weight (r = 0.51, P <.01; r = 0.37, P <.01; respectively). The correlation between umbilical cord insulin levels and birth weight was not statistically significant (r = 0.06, P =.63), nor was that between maternal body mass index and birth weight (r = 0.09, P =.50). CONCLUSION: Our data showed that umbilical cord leptin concentration was an independent risk factor for fetal macrosomia. |
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Authors:
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A Wiznitzer; B Furman; I Zuili; S Shany; E A Reece; M Mazor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 96 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-29 Completed Date: 2000-12-22 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 707-13 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Soroka Univeristy Medical Center and Temple University, Philadelphia, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Birth Weight* Female Fetal Blood / metabolism* Fetal Macrosomia / blood, etiology* Humans Infant, Newborn Insulin / blood Insulin-Like Growth Factor I / metabolism Leptin / blood* Male Pregnancy Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 11061-68-0/Insulin; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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