Document Detail


Cord gamma glutamyl transpeptidase activity and neonatal jaundice.
MedLine Citation:
PMID:  5963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
gamma Glutamyl transpeptidase (GGT) activity was measured in normal neonates and in maternal serum post partum. Levels were above the normal adult range (35I U/1) in all neonates and a significant correlation was bound between enzyme activity and bilirubin levels on day 7(P less than 0-005). The mean bilirubin level on days 4 and 7 was higher in babies with cord values less than 90 IU/1. In certain circumstances increased plasma GGT activity may serve as an index of enzyme induction. However, our results suggest that raised levels in the neonate may reflect hepatic microsomal damage with subsequent impairment of bilirubin conjugation. Further evaluative studies of cord GGT activity in neonates at risk, with a view to early prophylactic or therapeutic measures, are indicated.
Authors:
D C Davidson; W B McIntosh; J A Ford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  51     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  286-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood
Fetal Blood / enzymology
Humans
Infant, Newborn
Jaundice, Neonatal / blood,  enzymology*
gamma-Glutamyltransferase / metabolism*
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; EC 2.3.2.2/gamma-Glutamyltransferase
Comments/Corrections

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