Document Detail


Cord blood thyroid-stimulating hormone level in twin pregnancy.
MedLine Citation:
PMID:  12580836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cord blood thyroid-stimulating hormone level is elevated among neonates who undergo more perinatal stress. The aim of this study was to investigate the effect of twin pregnancy on the cord blood thyroid-stimulating hormone level. METHODS: The study group consisted of 24 910 singleton and 543 twin neonates over a 4-year period. The effect of twin pregnancy on the cord blood thyroid-stimulating level was evaluated. Linear regression analysis was used to control for the effect of mode of delivery, birth weight, and infant sex. RESULTS: The median cord blood thyroid-stimulating hormone levels (interquartile range) in the singletons and in the twins were 5.8mIU/l (4.2-8.6) and 5.6mIU/l (4.3-7.5), respectively. Linear regression analysis revealed no significant difference between singleton and twin cord blood thyroid-stimulating hormone levels (p = 0.23). Cord thyroid-stimulating hormone levels tended to be higher in second-born twins (p = 0.08) and monochorionic twins (p = 0.097) compared with singleton neonates. Twins with more than 20% weight discordance were associated with a significantly higher cord blood thyroid-stimulating hormone level (p = 0.035). CONCLUSION: Cord blood thyroid-stimulating hormone level is elevated in some subgroups of twins who are at higher risk of adverse perinatal outcomes. However, the overall effect of multiple pregnancy on the cord blood thyroid-stimulating hormone level is small. Cord blood thyroid-stimulating hormone screening for congenital hypothyroidism is also valid in twin pregnancies.
Authors:
Louis Yik-Si Chan; Pui Yu Chiu; Tze Kin Lau
Related Documents :
24259236 - The relationship between gestational weight gain and fetal growth: time to take stock?
22672446 - Serial magnetic resonance imaging of placenta percreta with bladder involvement during ...
7140486 - Abnormal gallbladder emptying in patients with gallstones.
23079776 - Screening for fetal growth disorders by clinical exam in the era of obesity.
22215716 - Glycogen phosphorylase isoenzyme bb plasma concentration is elevated in pregnancy and p...
54566 - Intensive antenatal plasmapheresis in severe rhesus isoimmunisation.
Publication Detail:
Type:  Comparative Study; Journal Article; Twin Study    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  82     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-02-12     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  28-31     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. lyschan@cuhk.edu.hk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Apgar Score
Birth Weight
Delivery, Obstetric / methods
Female
Fetal Blood / chemistry*
Gestational Age
Humans
Linear Models
Maternal Age
Pregnancy
Pregnancy Outcome*
Pregnancy, Multiple / blood*
Regression Analysis
Retrospective Studies
Thyrotropin / blood*
Twins
Chemical
Reg. No./Substance:
9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated maternal mid-trimester chorionic gonadotropin > or =4 MoM is associated with fetal cerebral...
Next Document:  Relationship between umbilical cord morphology and nuchal cord entanglement.