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Cord blood oxidative stress markers correlate with umbilical artery pulsatility in fetal growth restriction.
MedLine Citation:
PMID:  23130645     Owner:  NLM     Status:  Publisher    
Abstract Objective: To compare cord blood oxidative stress markers (OSM) between intrauterine small fetuses with high umbilical artery Doppler indices and normal indices. Methods: Forty women who had oligohydramnios and intrauterine growth-restricted fetuses with abnormal (n=20, group I) or normal Doppler indices (n=20, group II) were included. All patients underwent fetal Doppler ultrasound studies. Cord blood was collected at birth and six OSMs (ischemia modified albumin (IMA), hepatocyte growth factor (HGF), malondialdehyde (MDA)) levels, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) were studied. Results: The mean cord blood IMA, MDA, TOS, and OSI values for group I were significantly increased when compared to the group II (p<0.001 for IMA, MDA, TOS, and OSI). However the mean cord blood HGF and TAS values were statistically significantly decreased in group I, compared with group II (p<0.001 for HGF, and TAS). A significant positive (for IMA, MDA,TOS levels and OSI ratio) and negative (for HGF and TAS levels) correlations between umbilical artery pulsatility index and cord blood oxidative stress markers were found. Conclusion: The correlation between cord blood OSM and Doppler blood flow changes shown in this study may contribute to understanding the underlying oxidative stress-related mechanisms.
Emine Seda Guvendag Guven; Deniz Karcaaltincaba; Omer Kandemir; Sadiman Kiykac; Ahmet Mentese
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Recep Tayyip Erdogan University, School of Medicine, Dept of Ob & Gyn, Rize, Turkey.
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