Document Detail


Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities.
MedLine Citation:
PMID:  24123979     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: Osteopontin (OPN) is a pro-inflammatory cytokine associated with metabolic syndrome. Extreme birth weight categories including small for gestational age (SGA), and large for gestational age (LGA) are risk factors for metabolic syndrome. However, normal levels of plasma OPN in neonates, and the relationship of OPN to fetal growth remain unknown. We evaluated the association of umbilical cord blood OPN with gestational age, birth weight, and neonatal outcomes. Design and Methods: We performed a cross-sectional study of 261 newborns of all gestational ages beginning at week 26, and 26 adults for comparison. We collected umbilical cord blood from newborns and analyzed plasma for OPN by ELISA. Results: Plasma OPN was significantly higher in neonates (414.65±136.72 ng/mL) compared to adults (33.37±14.66 ng/mL, p<0.001). There was an inverse correlation between OPN and gestational age (r= -0.48, p<0.0001). LGA infants had lower OPN than appropriate for gestational age (AGA) infants, but LGA was not an independent predictor of OPN in multivariate analysis. Among preterm infants, patent ductus arteriosus (PDA) was independently associated with higher OPN (OR=2.49, p=0.02). Conclusion: Our results raise the possibility that OPN has a physiologic role in fetal growth and development, and may be a useful biomarker for PDA.
Authors:
Kyoung Eun Joung; Helen Christou; Kyung-Hee Park; Christos S Mantzoros
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-1
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Affiliation:
Division of Newborn Medicine, Boston Children's Hospital, Enders-961, 300 Longwood Ave, Boston, MA, 02115; Boston VA Health System and Harvard Medical School, 150 S Huntington Ave, Boston, MA, 02130.
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