Document Detail

Cord blood leptin levels in normal pregnancies, pregnancy induced hypertension and gestational diabetes mellitus.
MedLine Citation:
PMID:  18982799     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare cord blood leptin concentrations between normal pregnancy, pregnancy induced hypertension (PIH), and gestational diabetes mellitus (GDM). DESIGN: Cross-sectional study. SETTING: Academic institutes and a tertiary care maternal hospital. METHOD: 48 newborns of normal pregnancies (N=18), pregnancy induced hypertension (N=16), and gestational diabetes mellitus (N=14) were studied. Cord blood samples were collected and newborn anthropometric indices recorded at delivery. Leptin concentrations were measured using an enzyme immunoassay. RESULTS: Cord blood leptin levels were significantly different between the 3 groups (Kruskal-Wallis ANOVA; P=0.0064), and the difference resulted mainly from higher levels in GDM than in PIH [geometric mean (95% CI) for GDM: 10.89 (6.30, 18.84) vs PIH: 3.49 (2.14, 5.69) ng/ml (Dunn's multiple comparison: P<0.01). This pattern persisted even when leptin levels were normalized to the ponderal index (Kruskal-Wallis ANOVA P=0.0035; Dunn's multiple comparison: P<0.01). Leptin levels significantly and positively correlated with the ponderal index in normal pregnancy (Spearman r=0.506, p<0.05) and with birth weight in PIH (r=0.5463, p<0.05). CONCLUSION: In GDM cord blood leptin levels are significantly higher, and a source other than fetal adipocytes appears to contribute to this.
N Y Silva; K H Tennekoon; L Senanayake; E H Karunanayake
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Ceylon medical journal     Volume:  53     ISSN:  0009-0875     ISO Abbreviation:  Ceylon Med J     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1264702     Medline TA:  Ceylon Med J     Country:  Sri Lanka    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Institute of Biochemistry, Molecular Biology and Biotechnology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
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MeSH Terms
Birth Weight
Body Height
Cross-Sectional Studies
Diabetes, Gestational / blood*
Fetal Blood / chemistry*
Hypertension, Pregnancy-Induced / blood*
Infant, Newborn
Leptin / blood*
Pregnancy / blood*
Reg. No./Substance:

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