Document Detail

Cord blood hypertriglyceridaemia as an index of fetal stress: use of a simple screening test and results of further biochemical analysis.
MedLine Citation:
PMID:  638098     Owner:  NLM     Status:  MEDLINE    
In this preliminary study, 120 cord blood samples were subjected to a simple on-the-ward triglyceride screening procedure and 15 were designated as being high and another 15 randomly selected as controls. All the samples were then subjected to detailed biochemical analysis for fatty acid profiles and/or concentrations of free fatty acids, triglycerides (TG), phospholipids, cholesterol esters and glycerol. Eleven of the samples designated 'high' were associated with one or more of the following clinical conditions: family history of ischaemic heart disease, maternal starvation, fetal distress, light-for-dates babies and excessive weight gain during pregnancy. There was an association between high TG levels and high glycerol levels. The fatty acid pattern of the TG was altered when at abnormally high concentration, in particular oleic acid was increased relative to the others, and this was associated with an increase in cholesterol ester oleic acid. The possible mechanisms resulting in cord hypertriglyceridaemia are discussed.
M C Elphick; A T Harrison; J P Lawlor; D Hull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  85     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  303-10     Citation Subset:  AIM; IM    
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MeSH Terms
Cholesterol Esters / blood
Fatty Acids, Nonesterified / blood
Fetal Blood / analysis*
Fetal Distress / diagnosis*
Fetal Growth Retardation / complications
Glycerol / blood
Hyperlipidemias / complications,  genetics
Infant, Newborn
Phospholipids / blood
Pregnancy Complications / blood
Starvation / complications
Triglycerides / blood*
Reg. No./Substance:
0/Cholesterol Esters; 0/Fatty Acids, Nonesterified; 0/Phospholipids; 0/Triglycerides; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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