| Cord blood cortisol levels and respiratory distress syndrome. | |
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MedLine Citation:
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PMID: 7883344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cord blood cortisol levels were analyzed in 121 neonates, using a "Coat a Count" RIA kit. Forty two appropriate for gestation age (AGA) preterms < 34 weeks who had not received antenatal dexamethasone constituted Group A, 32 AGA preterms < 34 weeks gestation who had received dexamethasone antenatally comprised Group B, while Group C consisted of 47 term normal neonates. Cortisol levels were compared in these 3 groups and correlated to the development of respiratory distress syndrome (RDS). It was observed tht preterms (Groups A and B) had significantly (p < 0.005) lower levels (8.45 +/- 6.31 micrograms/dl) compared to term neonates (11.67 +/- 4.68 micrograms/dl). Antenatal dexamethasone therapy did not significantly alter cortisol levels within the group of preterms. There was a significant difference (p < 0.02) in cortisol levels between those preterms who developed RDS (5.41 +/- 4.91 micrograms/dl) and those who did not (9.58 +/- 6.45 micrograms/dl). Preterms (Grous A and B) who did not develop RDS had cortisol levels comparable to term neonates. There was a significant reduction in the incidence of RDS (p < 0.05) in preterms who had received antenatal dexamethasone. Cord blood cortisol levels < or = 7 micrograms/dl had a positive predictive accuracy of 36.59% and negative predictive accuracy of 93.75% in predicting onset of RDS. |
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Authors:
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T Srivastava; R H Merchant; M C Ambadekar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian pediatrics Volume: 31 ISSN: 0019-6061 ISO Abbreviation: Indian Pediatr Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-04-12 Completed Date: 1995-04-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: INDIA |
Other Details:
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Languages: eng Pagination: 923-8 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Bai Jerbai Wadia Hospital for Children, Parel, Bombay. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Dexamethasone / therapeutic use Fetal Blood / chemistry* Humans Hydrocortisone / blood* India / epidemiology Infant, Newborn Respiratory Distress Syndrome, Newborn / blood*, drug therapy, epidemiology, prevention & control |
| Chemical | |
Reg. No./Substance:
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50-02-2/Dexamethasone; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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