Document Detail


Cord blood cortisol levels and respiratory distress syndrome.
MedLine Citation:
PMID:  7883344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cord blood cortisol levels were analyzed in 121 neonates, using a "Coat a Count" RIA kit. Forty two appropriate for gestation age (AGA) preterms < 34 weeks who had not received antenatal dexamethasone constituted Group A, 32 AGA preterms < 34 weeks gestation who had received dexamethasone antenatally comprised Group B, while Group C consisted of 47 term normal neonates. Cortisol levels were compared in these 3 groups and correlated to the development of respiratory distress syndrome (RDS). It was observed tht preterms (Groups A and B) had significantly (p < 0.005) lower levels (8.45 +/- 6.31 micrograms/dl) compared to term neonates (11.67 +/- 4.68 micrograms/dl). Antenatal dexamethasone therapy did not significantly alter cortisol levels within the group of preterms. There was a significant difference (p < 0.02) in cortisol levels between those preterms who developed RDS (5.41 +/- 4.91 micrograms/dl) and those who did not (9.58 +/- 6.45 micrograms/dl). Preterms (Grous A and B) who did not develop RDS had cortisol levels comparable to term neonates. There was a significant reduction in the incidence of RDS (p < 0.05) in preterms who had received antenatal dexamethasone. Cord blood cortisol levels < or = 7 micrograms/dl had a positive predictive accuracy of 36.59% and negative predictive accuracy of 93.75% in predicting onset of RDS.
Authors:
T Srivastava; R H Merchant; M C Ambadekar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  31     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-04-12     Completed Date:  1995-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  923-8     Citation Subset:  IM    
Affiliation:
Division of Neonatology, Bai Jerbai Wadia Hospital for Children, Parel, Bombay.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Dexamethasone / therapeutic use
Fetal Blood / chemistry*
Humans
Hydrocortisone / blood*
India / epidemiology
Infant, Newborn
Respiratory Distress Syndrome, Newborn / blood*,  drug therapy,  epidemiology,  prevention & control
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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