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Cord blood chemokines differentiate between spontaneous and elective preterm births in singleton pregnancies.
MedLine Citation:
PMID:  21288736     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Signals originating from both maternal and fetal compartments participate in the preterm labor process. OBJECTIVE: To investigate whether cord blood immunoproteins predict spontaneous preterm labor. METHODS: Cord blood from 125 very preterm (gestational age <32weeks) singleton infants and 33 term infants was collected after birth and analyzed for 107 immunoproteins on microarrays. Immunoproteins from spontaneous preterm births (SPTB) were compared to immunoproteins from preterm births without labor. The placentas were studied for histology and immunohistochemistry. The data was modeled by classification and regression trees (CART) analysis. RESULTS: In preterm births, low CCL16 level predicted SPTB with a sensitivity of 94.7%, and specificity of 46.9%. According to logistic regression analysis, low CCL16 (OR 57.9), histologic chorioamnitis (OR 33.6), and high CCL23 (OR 44.6) were independent risk factors of SPTB. Cord blood CCL16 was higher in preterm births without labor and in term births than in SPTBs. CCL16 and its signaling receptor CCR1 were visualized in syncytiotrophoblast and cytotrophoblast cells of placental villi. CONCLUSION: Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth. Further studies are required to show whether CCL16 is involved in spontaneous preterm labor or in placental disease necessitating elective preterm delivery.
Authors:
Tuula Kaukola; Marja Ojaniemi; Jarno Tuimala; Riitta Herva; Timo Saarela; Stephen F Kingsmore; Mikko Hallman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-31
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, University of Oulu, FIN-90014 Oulu, Finland.
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