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Cord blood chemerin:Differential effects of gestational diabetes mellitus and maternal obesity.
MedLine Citation:
PMID:  23286837     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that fetal chemerin would be elevated in gestational diabetes mellitus (GDM) and correlate with fetal and maternal adiposity. DESIGN: Observational, longitudinal study SUBJECTS AND MEASUREMENTS: Fetal chemerin was measured separately in arterial and venous cord blood of 30 infants born to mothers with (n=15) and without GDM (n=15), in their mothers in early 3rd trimester and at delivery and in amniotic fluid (week 32) of women with GDM. Expression of chemerin and its receptor in human fetal tissues commercially available and in placental cells was measured by quantitative PCR. Associations between fetal and maternal anthropometric and metabolic variables were assessed in multivariate regression models. RESULTS: In GDM, fetal arterial, but not venous cord blood chemerin levels were elevated by about 60% (p <0.05). Venous cord blood chemerin was higher in infants of obese women (p<0.01). In multivariate analyses, neither amniotic fluid nor cord blood chemerin levels correlated with birth weight or ponderal index. Both arterial and venous chemerin levels were related to maternal chemerin at birth, and arterial chemerin was associated with GDM status in addition. Maternal levels were unaltered in GDM, but higher in maternal obesity. Fetal liver produces 4-fold more chemerin mRNA than other fetal tissues, whereas its receptor prevails in spleen. CONCLUSIONS: Based on multivariate analyses, fetal growth appears unrelated to fetal chemerin. Maternal obesity and GDM have differential effects on fetal chemerin levels. Site of major production (liver) and action (spleen) differ in human fetal tissues. © 2013 Blackwell Publishing Ltd.
Authors:
Mireille Nm van Poppel; Willibald Zeck; Daniela Ulrich; Eva-Christina Schest; Birgit Hirschmugl; Uwe Lang; Christian Wadsack; Gernot Desoye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Affiliation:
Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands.
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