Document Detail

Cord blood cellular proliferative response as a predictive factor for atopic dermatitis at 12 months.
MedLine Citation:
PMID:  23166412     Owner:  NLM     Status:  MEDLINE    
Since the risk of developing allergic disease increases in individuals exposed to allergens previously, even during the neonatal period, the immunologic status of a fetus may be important in the subsequent development of allergy. We evaluated the fetal factors to predict atopic dermatitis (AD) at 12 months in 412 infants of a COhort for Childhood Origin of Asthma and Allergic Diseases (COCOA) in the general Korean population. Cord blood mononuclear cells (CBMCs) were stimulated with ovalbumin and phytohemagglutinin and cellular proliferative response and concentrations of interleukin-13 and interferon-γ, were measured. The risk of developing AD was greater in boys than girls (OR 1.97, 95% CI 1.26-3.09), infants delivered by cesarean section than vaginally (OR 1.93, 95% CI 1.14-3.26) and infants with than without parental history of AD (OR 2.34, 95% CI 1.29-4.24). The CBMC proliferative response to phytohemagglutinin stimulation was higher in infants with than without AD (P = 0.048), but no difference was observed in ovalbumin-stimulated cells (P = 0.771). Risk factors for the development of AD at 12 months include male gender, delivery by cesarean section and parental history of AD. Increased CBMC proliferative response to phytohemagglutinin stimulation may predict the development of AD at 12 months.
Hyo-Bin Kim; Kang Mo Ahn; Kyung Won Kim; Youn Ho Shin; Jinho Yu; Ju-Hee Seo; Hyung Young Kim; Ji-Won Kwon; Byoung-Ju Kim; Ja-Young Kwon; Suk-Joo Choi; Kyung-Ju Lee; Hee Jin Park; Hye-Sung Won; Soo-Jong Hong
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-30
Journal Detail:
Title:  Journal of Korean medical science     Volume:  27     ISSN:  1598-6357     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-04-26     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  1320-6     Citation Subset:  IM    
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
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MeSH Terms
Cell Proliferation
Cesarean Section
Dermatitis, Atopic / diagnosis*,  metabolism
Fetal Blood / cytology*,  metabolism
Interferon-gamma / metabolism
Interleukin-13 / metabolism
Leukocytes, Mononuclear / drug effects,  metabolism*
Odds Ratio
Ovalbumin / toxicity
Phytohemagglutinins / toxicity
Predictive Value of Tests
Risk Factors
Sex Factors
Reg. No./Substance:
0/Interleukin-13; 0/Phytohemagglutinins; 82115-62-6/Interferon-gamma; 9006-59-1/Ovalbumin

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