| Cord blood carbohydrate-deficient transferrin levels are markedly higher than maternal. | |
| | |
MedLine Citation:
|
PMID: 9029385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Regular, heavy alcohol intake results in transferrin that is deficient in carbohydrate moieties. Carbohydrate-deficient transferrin (CDT) has been used as a biologic marker of heavy alcohol exposure in nonpregnant humans. There have been no reports of CDT levels in pregnancy. Our objective was to determine maternal and cord blood levels of CDT. Parturients were recruited at delivery based on graded representative alcohol consumption, from abstainers to heavy drinkers, as determined by screeners skilled at eliciting drug and alcohol histories. Maternal and cord blood serum samples were obtained at delivery. A double antibody radioimmunoassay was used to determine CDT in each sample. There were 83 paired specimens analyzed by paired t tests and stepwise regression analysis. Cord blood CDT units/liter (44.0 +/- 29.5) were significantly (P < 0.0001) higher than maternal (18.4 +/- 7.0). Maternal and cord CDT did not correlate with race, perinatal risk score, gestational age at delivery, birth weight, Apgar scores, or reported alcohol intake. Maternal CDT levels had a significant negative correlation with cigarette smoking. Cord blood CDT levels are significantly higher than maternal. While regular, heavy alcohol consumption by adults results in serum transferrin deficient in carbohydrate moieties, the reason for elevated fetal CDT is unknown. |
| | |
Authors:
|
J E Whitty; M P Dombrowski; S S Martier; M G Subramanian; R J Sokol |
Related Documents
:
|
6890235 - Maternal ethanol exposure induces transient impairment of umbilical circulation and fet... 19006995 - Screening and brief intervention in prenatal care settings. 19897225 - Effects of aqueous stable fullerene nanocrystals (nc60) on daphnia magna: evaluation of... 6751135 - Thiocyanate and drinking during pregnancy. 19001135 - Distinct trajectories of perinatal depressive symptomatology: evidence from growth mixt... 15302315 - Monozygotic twinning is not associated with zona pellucida micromanipulation procedures... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of maternal-fetal medicine Volume: 6 ISSN: 1057-0802 ISO Abbreviation: J Matern Fetal Med Publication Date: 1997 Jan-Feb |
Date Detail:
|
Created Date: 1997-06-19 Completed Date: 1997-06-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9211288 Medline TA: J Matern Fetal Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 45-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, Detroit, MI 48201, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Alcohol Drinking / blood*, epidemiology, ethnology Biological Markers / blood Ethnic Groups Female Fetal Blood / chemistry* Humans Incidence Maternal Exposure* Michigan / epidemiology Pregnancy Pregnancy Complications / blood*, enzymology, epidemiology Prenatal Exposure Delayed Effects* Transferrin / analogs & derivatives*, analysis |
| Grant Support | |
ID/Acronym/Agency:
|
5P50AA-0760608/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hepatic transplantation during pregnancy and the puerperium.
Next Document: Role of amniotic fluid in newborn acceptance and bonding in canines.