Document Detail


Cord blood and breast milk iron status in maternal anemia.
MedLine Citation:
PMID:  18310187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The purpose of this work was to assess the effect of severe maternal iron-deficiency anemia and nutritional status on cord blood and breast milk iron status. METHODS: We conducted a prospective observational study over a 6-month period in a teaching hospital in central India. The study population consisted of 55 anemic (hemoglobin: < 110 g/L) and 20 healthy nonanemic (hemoglobin: > or = 110 g/L) pregnant women who delivered singleton live births at term gestation. We measured hemoglobin, iron, and ferritin levels in paired maternal and cord blood and iron levels in early (day 3 +/- 1) and late (day 15 +/- 3) transitional milk. Maternal anthropometry, including weight, height, midarm circumference, triceps skinfold thickness, and placental weight, were recorded. The main outcome measure of the study was to find out the relationship of maternal hemoglobin, iron, ferritin, and anthropometry with hemoglobin, iron, and ferritin in cord blood and iron levels in breast milk. RESULTS: Concentrations of hemoglobin, iron, and ferritin were significantly lower in the cord blood of anemic mothers and showed linear relationships with maternal hemoglobin and ferritin levels. Breast milk iron content was significantly reduced in severely anemic mothers but not in those with mild-to-moderate anemia. Breast milk iron level correlated with maternal hemoglobin and iron levels but not with ferritin levels. Maternal anthropometry had significant correlations with indices of iron nutriture in maternal and cord blood but showed no relationship with breast milk iron content. Placental weight was comparable between anemic and nonanemic mothers. CONCLUSIONS: Maternal anemia, particularly the severe type, adversely affects cord blood and breast milk iron status. Maternal nutritional status exerts a significant influence on fetal iron status but has little influence on breast milk iron content.
Authors:
Ashok Kumar; Arun Kumar Rai; Sriparna Basu; Debabrata Dash; Jamuna Saran Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  121     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e673-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India. ashokkumar_bhu@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Anemia, Iron-Deficiency / diagnosis*,  epidemiology
Case-Control Studies
Female
Fetal Blood / chemistry*
Follow-Up Studies
Hemoglobins / analysis
Humans
Incidence
Infant, Newborn
Iron / analysis*
Milk, Human / chemistry*
Pregnancy
Pregnancy Complications, Hematologic / diagnosis*,  epidemiology
Pregnancy Outcome
Probability
Reference Values
Risk Assessment
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Hemoglobins; 7439-89-6/Iron

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