Document Detail

Cord blood adiponectin in large-for-gestational age newborns.
MedLine Citation:
PMID:  16157144     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth ("overweight"). STUDY DESIGN: Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-for-gestational age (LGA; 4297 +/- 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 +/- 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels. RESULTS: Mean adiponectin level was significantly lower in LGA newborns (29.4 +/- 13.8 vs 35.0 +/- 9.9 microg/mL, P < .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns. CONCLUSION: The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults.
Shali Mazaki-Tovi; Hannah Kanety; Clara Pariente; Rina Hemi; Eyal Schiff; Eyal Sivan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  193     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-10-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1238-42     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, and Institute of Endocrinology, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Adipose Tissue / physiology*
Birth Weight / physiology*
Fetal Blood / chemistry*
Fetus / physiology*
Infant, Newborn
Insulin / blood
Intercellular Signaling Peptides and Proteins / blood*
Leptin / blood
Reg. No./Substance:
0/Adiponectin; 0/Intercellular Signaling Peptides and Proteins; 0/Leptin; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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