| Cord Blood Vitamin D Deficiency is Associated With Respiratory Syncytial Virus Bronchiolitis. | |
MedLine Citation:
|
PMID: 21555499 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Respiratory syncytial virus (RSV) is the most important pathogen causing severe lower respiratory tract infection (LRTI) in infants. Epidemiologic and basic studies suggest that vitamin D may protect against RSV LRTI. Objective: To determine the association between plasma vitamin D concentrations at birth and the subsequent risk of RSV LRTI. Design: A prospective birth cohort study was performed in healthy term neonates. Concentrations of 25-hydroxyvitamin D (25-OHD) in cord blood plasma were related to RSV LRTI in the first year of life, defined as parent-reported LRTI symptoms in a daily log and simultaneous presence of RSV RNA in a nose-throat specimen. Results: The study population included 156 neonates. Eighteen (12%) developed RSV LRTI. The mean plasma 25-OHD concentration was 82 nmol/L. Overall, 27% of neonates had 25-OHD concentrations <50 nmol/L, 27% had 50-74 nmol/L and only 46% had 25-OHD 75 nmol/L. Cord blood 25-OHD concentrations were strongly associated with maternal vitamin D3 supplementation during pregnancy. Concentrations of 25-OHD were lower in neonates who subsequently developed RSV LRTI compared with those who did not (65 nmol/L versus 84 nmol/L, P = .009). Neonates born with 25-OHD concentrations <50 nmol/L had a sixfold (95% confidence interval: 1.6-24.9; P = .01) increased risk of RSV LRTI in the first year of life compared with those with 25-OHD concentrations ≥75 nmol/L. Conclusions: Vitamin D deficiency in healthy neonates is associated with increased risk of RSV LRTI in the first year of life. Intensified routine vitamin D supplementation during pregnancy may be a useful strategy to prevent RSV LRTI during infancy. |
Authors:
|
Mirjam E Belderbos; Michiel L Houben; Berry Wilbrink; Eef Lentjes; Eltje M Bloemen; Jan L L Kimpen; Maroeska Rovers; Louis Bont |
Related Documents
:
|
9633969 - Congenital malformations in victoria, australia, 1983-95: an overview of infant charact... 1574169 - Antiepileptics and the development of congenital anomalies. 6812389 - Embryotoxicity of industrial chemicals on the chicken embryo: thiourea derivatives. 20956899 - Congenital muscular torticollis: experience of 14 cases. 3973859 - Fetal heart rate tracings in fetuses with congenital malformations. 2403749 - Major congenital neurologic malformations. a 17-year survey. 1374349 - Accuracy of measurements of hbf with osm3 in neonates and infants. 25153209 - Is there a stepwise increase in neonatal morbidities according to histological stage (o... 887309 - Catecholamine release in the newborn infant at birth. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-9 |
Journal Detail:
|
Title: Pediatrics Volume: - ISSN: 1098-4275 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pediatrics. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Effect of Observation on Cranial Computed Tomography Utilization for Children After Blunt Head T...
Next Document: Preterm Birth and Inhaled Corticosteroid Use in 6- to 19-Year-Olds: A Swedish National Cohort Study.