Document Detail

Cord blood cardiac troponin T and nonprotein-bound iron levels in newborns of mild pre-eclamptic mothers.
MedLine Citation:
PMID:  19887861     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In hypoxic newborns, cardiac troponin T (cTnT) was shown to be an indicator of cardiac damage and increased levels of nonprotein-bound iron (NPBI), an indicator of increased free radical production and perinatal brain damage. OBJECTIVE: The aim of this study was to determine cord blood cTnT and NPBI levels in neonates of mild pre-eclamptic mothers. METHODS: The study included 50 babies of mild pre-eclamptic mothers and 50 babies of healthy mothers. cTnT and NPBI levels were measured in cord blood. RESULTS: The mean gestational age in the pre-eclamptic and healthy groups were 36.1 +/- 3.5 and 38.1 +/- 1.9 weeks, mean birth weights were 2,456 +/- 945 and 3,059 +/- 493 g. Cord blood median cTnT level was significantly higher in the pre-eclamptic group (0.024 vs. 0.015 ng/ml). Serum cTnT in the 95th percentile was 0.047 ng/ml in the healthy group. cTnT levels of preterm babies in the pre-eclamptic group was found to be significantly higher compared to term babies in the control group (0.038 vs. 0.013 ng/ml). It could not be demonstrated whether there is a statistically significant relation between cTnT levels and respiratory distress, gestation, type of delivery, sex and birth weight. The median NPBI level was higher in the control group (3.26 vs. 1.86 micromol/l). CONCLUSIONS: Increased levels of cTnT may be a biochemical marker of cardiac involvement in babies of mild pre-eclamptic mothers. In this study, no correlation was found between cTnT levels and NPBI levels.
Leyla Karadeniz; Asuman Coban; Zeynep Ince; Umit Turkoglu; Gulay Can
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-04
Journal Detail:
Title:  Neonatology     Volume:  97     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  305-10     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Division of Neonatology, Department of Pediatrics, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Apgar Score
Biological Markers / blood
Birth Weight / physiology
Case-Control Studies
Fetal Blood / chemistry,  metabolism*
Gestational Age
Infant, Newborn
Iron / analysis,  blood*,  metabolism
Myocardium / metabolism
Pre-Eclampsia* / pathology
Protein Binding
Severity of Illness Index
Troponin T / analysis,  blood*,  metabolism
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; 7439-89-6/Iron

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