Document Detail


The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium.
MedLine Citation:
PMID:  18676664     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.
Authors:
Krisztina M Papp-Wallace; Margaret Nartea; David G Kehres; Steffen Porwollik; Michael McClelland; Stephen J Libby; Ferric C Fang; Michael E Maguire
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-01
Journal Detail:
Title:  Journal of bacteriology     Volume:  190     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2009-01-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6517-23     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4965, USA. kmp12@po.cwru.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Proteins / genetics,  metabolism*,  physiology
Blotting, Western
Caco-2 Cells
Cation Transport Proteins / genetics,  metabolism*,  physiology
Humans
Magnesium / metabolism*
Mice
Mice, Inbred BALB C
Mutation
Oligonucleotide Array Sequence Analysis
Salmonella Infections, Animal / microbiology
Salmonella typhimurium / genetics,  metabolism*,  pathogenicity
Virulence / genetics
Grant Support
ID/Acronym/Agency:
AI052237/AI/NIAID NIH HHS; AI057733/AI/NIAID NIH HHS; AI34829/AI/NIAID NIH HHS; AI44486/AI/NIAID NIH HHS; AI48622/AI/NIAID NIH HHS; GM08803/GM/NIGMS NIH HHS; GM39447/GM/NIGMS NIH HHS; T32 AI-07024/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Cation Transport Proteins; 0/CorA protein, Salmonella; 7439-95-4/Magnesium
Comments/Corrections

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