| Copy number imbalances in blood and hair in monozygotic twins discordant for amyotrophic lateral sclerosis. | |
| | |
MedLine Citation:
|
PMID: 21741244 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Chromosomal copy number association studies in patients with amyotrophic lateral sclerosis (ALS) using blood DNA have so far been inconclusive. We employed genome-wide screening to look for copy number imbalances (CNIs) between blood and hair DNA from three ALS-discordant monozygotic twin pairs and two phenotypically normal monozygotic twin pairs. Genome-wide chromosomal copy number was estimated using AffyMetrix 6.0 GeneChips. CNIs were sought both between twin pairs and between blood and hair DNA from the same individuals. Two blood CNIs were found in one ALS-discordant twin pair. In another ALS-discordant twin pair, seven hair CNIs were detected. CNIs were also found between blood and hair in three individuals. Imbalances in blood copy number appear to be rare in monozygotic twin pairs, but hair may harbour more CNIs than blood. Copy number differences between blood and hair from the same individuals appear to be common. Since brain and hair share a common ectodermal origin, hair may be a more suitable tissue than blood to estimate somatic copy number variation in the brain. |
| | |
Authors:
|
Roger Pamphlett; Julia M Morahan |
Related Documents
:
|
1355704 - Technical progress in parentage analysis. 6885084 - Low haemoglobin levels in a1 and o blood groups. 20427174 - Nasopharyngeal cancer detection based on blood plasma surface-enhanced raman spectrosco... 6175824 - Vascular effects of prazosin on normothermic and hypothermic perfusion in the isolated ... 8708684 - Dynamics of cerebral blood flow and metabolism in patients with cranioplasty as evaluat... 1415694 - Effects of peptide yy on the human cardiovascular system: reversal of responses to vaso... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-6 |
Journal Detail:
|
Title: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Volume: - ISSN: 1532-2653 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9433352 Medline TA: J Clin Neurosci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
The Stacey Motor Neuron Disease Laboratory, Department of Pathology D06, University of Sydney, Sydney, New South Wales 2006, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In-shoe plantar pressure measurements for patients with knee osteoarthritis: Reliability and effects...
Next Document: Awake far lateral craniotomy for resection of foramen magnum meningioma in a patient with tenuous mo...