Document Detail


Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer.
MedLine Citation:
PMID:  25169130     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Protein tyrosine phosphatases that act in different cellular pathways are described most commonly as tumor suppressors, but also as oncogenes. Their role has previously been described in colorectal cancer, as well as in gastric, breast, thyroid, prostate, ovarian, pancreatic, glioma, liver, leukemia and many other cancers. In a previous study, we have described protein tyrosine phosphatase receptor type T, M, Z1 and Q genes (PTPRT, PTPRM, PTPRZ1 and PTPRQ) hypermethylated in sporadic colorectal cancer. Thus, in this study, we examined the relation of unbalanced chromosomal alterations within regions covering these four protein tyrosine phosphatase genes with this cancer. One hundred and two cancer tissues were molecularly characterized, including analysis of the BRAF and K-ras mutations and methylator phenotype. The analysis of chromosomal aberrations was performed using Comparative Genomic Hybridization. We observed amplification of three regions containing genes coding for PTPs, such as PTPRM (7q31.2, amplified in 21% of cases), PTPRQ (12q21.2, amplified in 5.5% of cases), PTPRT (20q12, amplified in 27.5% of cases), along with deletions in the region of PTPRZ1 (18p11.2, deleted in 20% of cases). These data may suggest that in sporadic colorectal cancer PTPRM, PTPRT, PTPRQ probably act as oncogenes, while PTPRZ1 acts as a tumor suppressor gene. Our study also revealed that gains on chromosome 20q12 and losses on chromosome 18p11.2 are connected with the absence of the BRAF mutation and the conventional adenocarcinoma pathway.
Authors:
Izabela Laczmanska; Pawel Karpinski; Joanna Kozlowska; Marek Bebenek; David Ramsey; Tomasz Sedziak; Piotr Ziolkowski; Maria M Sasiadek
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-9
Journal Detail:
Title:  Pathology, research and practice     Volume:  -     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier GmbH. All rights reserved.
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