Document Detail

Copulatory thrusting pattern in the male rat after acute treatment with GABA transaminase inhibitors.
MedLine Citation:
PMID:  2159160     Owner:  NLM     Status:  MEDLINE    
It has previously been found that the GABA transaminase inhibitors gamma-acetylen GABA (GAG) and sodium valproate reduced intromission behavior in male rats without affecting mounting behavior. These effects were obtained, however, only in doses that also impaired motor execution. The purpose of the present study was to establish whether copulatory thrusting patterns were affected by these GABA transaminase inhibitors. Sodium valproate, 200 mg/kg, reduced the number of intromissions and the intromission rate without affecting mounting behavior. GAG, 100 mg/kg, had similar effects on sexual behavior. The only effect obtained on copulatory thrusting patterns was a small reduction in mount and intromission thrust frequency after GAG 100 mg/kg. It is unlikely that this effect is responsible for the inhibitory actions of GAG on sexual behavior, especially since sodium valproate did not modify copulatory thrusting patterns, but inhibited sexual behavior in a manner similar to that of GAG.
A Agmo; J L Contreras
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  47     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-06-05     Completed Date:  1990-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-4     Citation Subset:  IM    
Escuela de Psicología, Universidad Anáhuac, México DF.
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MeSH Terms
4-Aminobutyrate Transaminase / antagonists & inhibitors*
Aminocaproic Acids / pharmacology*
Copulation / drug effects*
Penile Erection / drug effects
Rats, Inbred Strains
Receptors, GABA-A / drug effects*
Valproic Acid / pharmacology*
Reg. No./Substance:
0/Alkynes; 0/Aminocaproic Acids; 0/Receptors, GABA-A; 57659-38-8/4-amino-5-hexynoic acid; 99-66-1/Valproic Acid; EC Transaminase

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