Document Detail

Copper- and zinc-enriched mycelium of Agaricus blazei Murrill: bioaccumulation and bioavailability.
MedLine Citation:
PMID:  17472484     Owner:  NLM     Status:  MEDLINE    
Agaricus blazei is an edible mushroom with medicinal properties. To obtain organic combinations of potential utility as a food dietary supplement, the accumulation and potential bioavailability of copper (Cu) and zinc (Zn) on mycelium grown in the presence of these metals were studied. At 400 ppm, the mycelium accumulated 449 and 163 times the basal content of Cu and Zn, respectively. When mycelia cultivated with nonmycotoxic concentrations of Cu or Zn (100 and 200 ppm) were subjected to sequential chemical extraction and simulated gastrointestinal digestion, close to 90% of the metals accumulated in the available nonresidual fraction, which was similar to or better than the values found in two commercial supplements. The solubility in the simulated digestive fluids was 30-34% and 18-33%, i.e., 60-98% and 9-11% of the recommended daily intake for Cu and Zn, respectively, with only 1 g of mycelium.
Maia Rabinovich; Débora Figlas; Silvia Delmastro; Néstor Curvetto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  10     ISSN:  1096-620X     ISO Abbreviation:  J Med Food     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-02     Completed Date:  2007-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Departamento de Agronomía, Universidad Nacional del Sur, Bahía Blanca, Argentina.
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MeSH Terms
Agaricus / chemistry*,  growth & development
Biological Availability
Copper / administration & dosage,  analysis*,  pharmacokinetics
Models, Biological
Mycelium / chemistry*,  growth & development
Zinc / administration & dosage,  analysis*,  pharmacokinetics
Reg. No./Substance:
7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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