| Copper supplementation in parenteral nutrition of cholestatic infants. | |
| | |
MedLine Citation:
|
PMID: 20400915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVES: Conventional practice is to reduce or eliminate copper (Cu) supplementation in the parenteral nutrition of infants with cholestasis because of the increased risk of hepatotoxicity. However, there are reports of Cu deficiency in cholestatic infants because of Cu reduction in their parenteral nutrition. The objectives of the present study are to determine the proportion of cholestatic infants who develop elevated serum Cu while receiving a nonreduced dose of parenteral Cu, to evaluate potential clinical factors that affect serum Cu in cholestatic infants, and to evaluate the impact of serum Cu on liver disease. PATIENTS AND METHODS: This is a retrospective review of 28 cholestatic infants receiving 20 microg x kg(-1) x day(-1) of Cu via parenteral nutrition. Age-adjusted references were used to determine normality of serum Cu levels. Multiple linear regression analyses were performed to determine predictors of serum Cu and alanine aminotransferase (ALT). RESULTS: Serum Cu levels were elevated in 2 infants (7%). On average, infants received 80% of their energy intake from parenteral nutrition for 3 months. Intestinal failure was present in 50% of the patients. Birth weight, gestational age, and ALT were identified as predictors of serum Cu (R2 = 0.53; P = 0.0001). Serum Cu, gestational age, and total bilirubin were associated with serum ALT (R2 = 0.43; P = 0.001). CONCLUSIONS: Supplementation of parenteral Cu at 20 microg x kg(-1) x day(-1) does not lead to a significant increase in Cu toxicity or worsening of liver disease in cholestatic infants. |
| | |
Authors:
|
Juliana Frem; Yvonne Sarson; Tom Sternberg; Conrad R Cole |
Related Documents
:
|
18070015 - Gallstones and clonorchis sinensis infection: a hospital-based case-control study in ko... 20513975 - Liver fibrosis in an extremely small infant for gestational age. 227825 - Postnatal changes in the distribution of lipid droplets within the liver lobule of the ... 1801985 - Case of biliary lithiasis in an infant. 20336465 - Three distinct episodes of gbs septicemia in a healthy newborn during the first month o... 20456275 - Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm in... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pediatric gastroenterology and nutrition Volume: 50 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-26 Completed Date: 2010-11-23 Revised Date: 2011-08-29 |
Medline Journal Info:
|
Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 650-4 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA. fremjulianac@uams.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine Transaminase
/
blood Bilirubin / blood Birth Weight Cholestasis / blood* Copper / administration & dosage, adverse effects*, blood Dietary Supplements* Energy Intake Gestational Age Humans Infant Intestinal Diseases Liver Diseases / blood* Parenteral Nutrition / methods* Regression Analysis Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
|
1KL2RR025009/RR/NCRR NIH HHS; 5K12RR017643/RR/NCRR NIH HHS; M01 RR000039-475518/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
635-65-4/Bilirubin; 7440-50-8/Copper; EC 2.6.1.2/Alanine Transaminase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Esophageal motility in children with suspected gastroesophageal reflux disease.
Next Document: Efficacy of Lactobacillus GG in aboriginal children with acute diarrhoeal disease: a randomised clin...