Document Detail


Copper-Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Temperature.
MedLine Citation:
PMID:  22458339     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A copper-mediated ligandless aerobic fluoroalkylation of aryl boronic acids under mild conditions was described, for the first time. The reaction tolerates a wide range of functional groups, thus allowing for further transformation. Mechanistic studies suggest that [RfCu] was the active copper species that formed the desired perfluoroalkylarenes and [RfCu] was generated from [PhCu] either by a oxidative-addition/reductive-elimination mechanism or by a nucleophilic substitution via a halogen "ate'' inte-rmediate.
Authors:
Qingqing Qi; Qilong Shen; Long Lu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-29
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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