Document Detail

Copper and iron homeostasis in plants: the challenges of oxidative stress.
MedLine Citation:
PMID:  23199018     Owner:  NLM     Status:  MEDLINE    
SIGNIFICANCE: Photosynthesis, the process that drives life on earth, relies on transition metal (e.g., Fe and Cu) containing proteins that participate in electron transfer in the chloroplast. However, the light reactions also generate high levels of reactive oxygen species (ROS), which makes metal use in plants a challenge.
RECENT ADVANCES: Sophisticated regulatory networks govern Fe and Cu homeostasis in response to metal ion availability according to cellular needs and priorities. Molecular remodeling in response to Fe or Cu limitation leads to its economy to benefit photosynthesis. Fe toxicity is prevented by ferritin, a chloroplastic Fe-storage protein in plants. Recent studies on ferritin function and regulation revealed the interplay between iron homeostasis and the redox balance in the chloroplast.
CRITICAL ISSUES: Although the connections between metal excess and ROS in the chloroplast are established at the molecular level, the mechanistic details and physiological significance remain to be defined. The causality/effect relationship between transition metals, redox signals, and responses is difficult to establish.
FUTURE DIRECTIONS: Integrated approaches have led to a comprehensive understanding of Cu homeostasis in plants. However, the biological functions of several major families of Cu proteins remain unclear. The cellular priorities for Fe use under deficiency remain largely to be determined. A number of transcription factors that function to regulate Cu and Fe homeostasis under deficiency have been characterized, but we have not identified regulators that mediate responses to excess. Importantly, details of metal sensing mechanisms and cross talk to ROS-sensing mechanisms are so far poorly documented in plants.
Karl Ravet; Marinus Pilon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2013-01-23
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  19     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-30     Completed Date:  2014-03-06     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  919-32     Citation Subset:  IM    
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MeSH Terms
Chloroplasts / metabolism
Copper / metabolism*,  toxicity
Iron / metabolism*,  toxicity
Metals / metabolism
Oxidative Stress
Plants / drug effects,  metabolism*
Plastocyanin / metabolism
Reactive Oxygen Species / metabolism
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Metals; 0/Reactive Oxygen Species; 789U1901C5/Copper; 9014-09-9/Plastocyanin; E1UOL152H7/Iron; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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