Document Detail


Copper-catalyzed chlorination of functionalized arylboronic acids.
MedLine Citation:
PMID:  20184339     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A mild, efficient, Cu(I)-catalyzed method for the conversion of arylboronic acids to aryl chlorides is reported. This method is particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient in the absence of Cu catalysis.
Authors:
Hong Wu; John Hynes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Organic letters     Volume:  12     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1192-5     Citation Subset:  IM    
Affiliation:
Discovery Chemistry, Bristol-Myers Squibb Company, PO Box 4000, Princeton New Jersey 08543, USA.
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MeSH Terms
Descriptor/Qualifier:
Boronic Acids / chemistry*
Catalysis
Copper / chemistry*
Hydrocarbons, Chlorinated / chemical synthesis*,  chemistry
Molecular Structure
Stereoisomerism
Chemical
Reg. No./Substance:
0/Boronic Acids; 0/Hydrocarbons, Chlorinated; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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