Document Detail


Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids.
MedLine Citation:
PMID:  23088256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate.
Authors:
Yong Wook Kim; Micah J Niphakis; Gunda I Georg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-22
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  77     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-02     Completed Date:  2013-03-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9496-503     Citation Subset:  IM    
Affiliation:
Department of Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.
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MeSH Terms
Descriptor/Qualifier:
Amines / chemistry*
Boronic Acids / chemistry*
Catalysis
Copper / chemistry*
Heterocyclic Compounds / chemistry*
Molecular Structure
Palladium / chemistry*
Grant Support
ID/Acronym/Agency:
GM081267/GM/NIGMS NIH HHS; P41 GM081267/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amines; 0/Boronic Acids; 0/Heterocyclic Compounds; 7440-05-3/Palladium; 7440-50-8/Copper
Comments/Corrections

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