| Copper-assisted palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. | |
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MedLine Citation:
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PMID: 23088256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate. |
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Authors:
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Yong Wook Kim; Micah J Niphakis; Gunda I Georg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-22 |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 77 ISSN: 1520-6904 ISO Abbreviation: J. Org. Chem. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-02 Completed Date: 2013-03-17 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 9496-503 Citation Subset: IM |
Affiliation:
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Department of Chemistry, and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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chemistry* Boronic Acids / chemistry* Catalysis Copper / chemistry* Heterocyclic Compounds / chemistry* Molecular Structure Palladium / chemistry* |
| Grant Support | |
ID/Acronym/Agency:
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GM081267/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Boronic Acids; 0/Heterocyclic Compounds; 7440-05-3/Palladium; 7440-50-8/Copper |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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