Document Detail


Coordination of cell cycle exit and differentiation of neuronal progenitors.
MedLine Citation:
PMID:  18239460     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During development, co-ordinate regulation of cell cycle exit and differentiation of neuronal precursors is essential for generation of appropriate number of neurons and proper wiring of neuronal circuits. Recent studies have identified some of the molecules implicated in the regulation of these cellular events, but the complex machinery that orchestrates these processes into a coherent developmental program remains unclear. BM88/Cend1 is a neuronal protein associated in vivo with terminal neuron-generating divisions, marking the exit of proliferative cells from the cell cycle. Genetic studies in neural cell lines, neural stem/progenitor cells using the neurosphere system and in the developing chicken neural tube in vivo have shown that BM88/Cend1 is a dual function molecule co-ordinating cell cycle exit and differentiation of neuronal progenitors. These studies have thus shed light on a molecular determinant that participates, along with other known and possibly still unknown regulators, in the complex processes by which a progenitor cell becomes a mature neuron.
Authors:
Panagiotis K Politis; Dimitra Thomaidou; Rebecca Matsas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-01-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  7     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-09-15     Revised Date:  2010-09-22    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
Affiliation:
Center of Basic Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece. ppolitis@bioacademy.gr
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology*
Cell Differentiation / physiology*
Chick Embryo
Humans
Models, Biological
Nerve Tissue Proteins / metabolism*
Nervous System / embryology*
Neurons / physiology*
Signal Transduction / physiology*
Chemical
Reg. No./Substance:
0/CEND1 protein, human; 0/Nerve Tissue Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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