Document Detail

Coordination of calcium signals by pituitary endocrine cells in situ.
MedLine Citation:
PMID:  22172406     Owner:  NLM     Status:  Publisher    
The pulsatile secretion of hormones from the mammalian pituitary gland drives a wide range of homeostatic responses by dynamically altering the functional set-point of effector tissues. To accomplish this, endocrine cell populations residing within the intact pituitary display large-scale changes in coordinated calcium-spiking activity in response to various hypothalamic and peripheral inputs. Although the pituitary gland is structurally compartmentalized into specific and intermingled endocrine cell networks, providing a clear morphological basis for such coordinated activity, the mechanisms which facilitate the timely propagation of information between cells in situ remain largely unexplored. Therefore, the aim of the current review is to highlight the range of signalling modalities known to be employed by endocrine cells to coordinate intracellular calcium rises, and discuss how these mechanisms are integrated at the population level to orchestrate cell function and tissue output.
David J Hodson; Nicola Romanò; Marie Schaeffer; Pierre Fontanaud; Chrystel Lafont; Tatiana Fiordelisio; Patrice Mollard
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-13
Journal Detail:
Title:  Cell calcium     Volume:  -     ISSN:  1532-1991     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006226     Medline TA:  Cell Calcium     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
CNRS, UMR-5203, Institut de Génomique Fonctionnelle, F-34000 Montpellier, France; INSERM, U661, F-34000 Montpellier, France; Universités de Montpellier 1 & 2, UMR-5203, F-34000 Montpellier, France.
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