| Coordination sphere tuning of the electron transfer dissociation behavior of Cu(II)-peptide complexes. | |
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MedLine Citation:
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PMID: 22161629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In contrast to previous electron capture dissociation (ECD) studies, we find that electron transfer dissociation (ETD) of Cu(II)-peptide complexes can generate c- and z-type product ions when the peptide has a sufficient number of strongly coordinating residues. Double-resonance experiments, ion-molecule reactions, and collision-induced dissociation (CID) prove that the c and z product ions are formed via typical radical pathways without the associated reduction of Cu(II), despite the high second ionization energy of Cu. A positive correlation between the number of Cu(II) binding groups in the peptide sequence and the extent of c and z ion formation was also observed. This trend is rationalized by considering that the recombination energy of Cu(II) can be lowered by strong binding ligands to an extent that enables electron transfer to non-Cu sites (e.g., protonation sites) to compete with Cu(II) reduction, thereby generating c/z ions in a manner similar to that observed for protonated (i.e., nonmetalated) peptides. |
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Authors:
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Jia Dong; Richard W Vachet |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-12-09 |
Journal Detail:
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Title: Journal of the American Society for Mass Spectrometry Volume: 23 ISSN: 1879-1123 ISO Abbreviation: J. Am. Soc. Mass Spectrom. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: 2012-03-28 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 9010412 Medline TA: J Am Soc Mass Spectrom Country: United States |
Other Details:
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Languages: eng Pagination: 321-9 Citation Subset: IM |
Copyright Information:
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© American Society for Mass Spectrometry, 2011 |
Affiliation:
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Department of Chemistry, University of Massachusetts, LGRT 701, 10 N. Pleasant St., Amherst, MA 01003, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Coordination Complexes / chemistry* Copper / chemistry* Molecular Sequence Data Peptides / chemistry* Spectrometry, Mass, Electrospray Ionization Tandem Mass Spectrometry / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM 075092/GM/NIGMS NIH HHS; R01 GM075092-07/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coordination Complexes; 0/Peptides; 7440-50-8/Copper |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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