Document Detail


Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro.
MedLine Citation:
PMID:  23183355     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Suckling is a rhythmic jaw movement that is symmetrical on the left and right side and is highly coordinated with tongue movement. Thus, we investigated the neuronal mechanisms of the left/right and jaw/tongue coordinations during N-methyl-D-aspartate (NMDA)-induced fictive suckling using isolated brainstem-spinal cord preparations obtained from neonatal mice. We observed synchronous low-frequency rhythmic activity in the left/right trigeminal motor nerves, which differed from respiration, and high-frequency rhythmic trigeminal activity, which was side-independent. The low-frequency rhythmic trigeminal activity was also synchronized with the hypoglossal nerve activity. After a complete midline separation of the preparation or a partial midline transection of the brainstem from the anterior inferior cerebellar artery to the junction of the vertebral artery, the low-frequency rhythmic trigeminal activity disappeared, whereas the high-frequency rhythmic trigeminal activity and low-frequency rhythmic hypoglossal activity still remained. These results suggest that the neuronal network that generates low-frequency rhythmic activity likely contributes to the synchronized activity of the left/right jaw muscles and to the jaw/tongue muscles, where it sends its command to the trigeminal motoneurons mainly via the commissural pathway that crosses the transected midline region. Such a neuronal network may underlie the coordinated movements of the jaw and tongue during suckling.
Authors:
Yoshiaki Ihara; Kiyomi Nakayama; Shiro Nakamura; Ayako Mochizuki; Koji Takahashi; Tomio Inoue
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-23
Journal Detail:
Title:  Neuroscience research     Volume:  -     ISSN:  1872-8111     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Oral Rehabilitation, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan; Department of Oral Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
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