| Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress. | |
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MedLine Citation:
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PMID: 21062910 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Macroautophagy is a cellular degradation mechanism that involves the delivery of cytosolic components (macromolecules or organelles) by the autophagosome to the lysosome for degradation. In mammalian cells, macroautophagy and the ubiquitin proteasome system are 2 major mechanisms to eliminate abnormal proteins accumulated in pathological conditions. Here, the coordination of the 2 pathways to alleviate endoplasmic reticulum stress is reviewed. Also discussed is the regulatory role of macroautophagy and proteasome activity in cell survival and death, as well as the recent discoveries leading to novel strategies of simultaneous control of the proteasome and autophagy activity in anticancer treatment. |
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Authors:
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X Chen; X-M Yin |
Publication Detail:
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Type: Journal Article Date: 2010-11-09 |
Journal Detail:
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Title: Veterinary pathology Volume: 48 ISSN: 1544-2217 ISO Abbreviation: Vet. Pathol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: IM |
Affiliation:
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MD, PhD, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Rm 6016A, Indianapolis, IN 46202 Email: xmyin@iupui.edu. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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